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LABORATÓRIO DE TECNOLOGIA DE MEDICAMENTOS, ALIMENTOS E COSMÉTICOS

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FERREIRA-NUNES, R.; FERREIRA, L.; GRATIERI, T.; CUNHA-FILHO, M.; GELFUSO, G. M. Stability-indicating analytical method of quantifying spironolactone and canrenone in dermatological formulations and iontophoretic skin permeation experiments. Biomedical  Chromatograpgy, 2019.

 

CUNHA-FILHO, M.; TEIXEIRA, M. T. ; SANTOS-ROSALES, V.; SA-BARRETO, L. L.; MARRETO, R. N.; MARTIN-PASTOR, M.; GARCÍA-GONZÁLEZ, C. A.; LANDIN, M. The subdivision behavior of polymeric tablets. International Journal of Pharmaceutics, v. 568, p. 118554, 2019.

PIRES, F. Q.; DA SILVA, J. K. R.; SA-BARRETO, L. L.; GRATIERI, T.; GELFUSO, G. M.; CUNHA-FILHO, M. Lipid nanoparticles as carriers of cyclodextrin inclusion complexes: a promising approach for cutaneous delivery of a volatile essential oil. Colloids and Surfaces B - Biointerfaces, v. 182, p. 110382, 2019.

REIS, T. A.; JACULI, A. E.; RAMOS, K. L. V.; SOUZA, P. E. N.; VEIGA-SOUZA, F. H.; JOANITTI, G. A.; AZEVEDO, R. B.; GRATIERI, T.; CUNHA-FILHO, M.; GELFUSO, G. M. Combination of cyclodextrin complexation and iontophoresis as a promising strategy for the cutaneous delivery of aluminum-chloride phthalocyanine in photodynamic therapy. European Journal of Pharmaceutical Sciences, p. 105056, 2019.

 

GELFUSO, G. M.; CUNHA-FILHO, M. S. S.; GRATIERI, T. Overcoming hurdles in iontophoretic drug delivery: is skin the only barrier?: an update. Therapeutic Delivery. v. 10, p. 211-214, 2019.

ARAUJO, M. R. P.; BARRETO, L. C. S.; GRATIERI, T.; GELFUSO, G. M.; CUNHA-FILHO, M. S. S. The digital pharmacies era: how 3D printing technology using fused deposition modeling can become a reality. Pharmaceutics v.11, p.128, 2019.

SILVA, S. M. M.; COSTA, C. R. R.; GELFUSO, G. M.; GUERRA, E. N. S.; NOBREGA, Y. K. M.; GOMES, S. M.; PIC-TAYLOR, A.; FONSECA-BAZZO, Y. M.; SILVEIRA, D.; MAGALHAES, P. O. Wound Healing Effect of Essential Oil Extracted from Eugenia dysenterica DC (Myrtaceae) Leaves. Molecules, v. 24, p. 2, 2019.

KOLLROSS, B.; GELFUSO, G. M.; CUNHA-FILHO, M. S. S.; GRATIERI, T. Topical ophthalmic antimicrobials: unfulfilled demands and possibility of new investments in Brazil and in the United States. Brazilian Journal of Pharmaceutical Sciences (Online), 2019 (publicado online)

KOLLROSS, B.; CUNHA FILHO, M. S. S.; GELFUSO, G. M.; GRATIERI, T. Regulatory Requirements and Innovation. Therapeutic Innovation & Regulatory Science, p. 216847901879179, 2018.

PIRES, F. Q.; PINHO, L. A.; FREIRE, D. O.; SILVA, I. C. R.; SA-BARRETO, LIVIA L.; CARDOZO-FILHO, L.; GRATIERI, T.; GELFUSO, G. M.; CUNHA-FILHO, M. Thermal analysis used to guide the production of thymol and Lippia origanoides essential oil inclusion complexes with cyclodextrin. Journal of Thermal Analysis And Calorimetry, 2018 (publicado online).

PEREIRA, M. N.; USHIROBIRA, C. Y.; CUNHA FILHO, M. S. S.; GELFUSO, G. M.; GRATIERI, T. Nanotechnology advances for hair loss. Therapeutic Delivery, v. 9, p. 593-603, 2018.

FERREIRA-NUNES, R.; DA SILVA, S. M. M.; DE SOUZA, P. E. N.; MAGALHÃES, P. O.; CUNHA-FILHO, M.; GRATIERI, T.; GELFUSO, G. M.Incorporation of Eugenia dysenterica extract in microemulsions preserves stability, antioxidant effect and provides enhanced cutaneous permeation. Journal of Molecular Liquids, v. 265, p. 408-415, 2018.

SANTOS, G.A.; ANGELO, T.; ANDRADE, L. M.; SILVA, S.M.M.; MAGALHÃES, P.O.; CUNHA-FILHO, M.; GELFUSO, G.M.; TAVEIRA, S.F.; GRATIERI, T. The role of formulation and follicular pathway in voriconazole cutaneous delivery from liposomes and nanostructured lipid carriers. Colloids & Surfaces B: Biointerfaces, v. 170, p. 341-346, 2018.

PEREIRA, M. N.; MATOS, B. N.; GRATIERI, T.; CUNHA-FILHO, M.; GELFUSO, G. M.Development and validation of a simple chromatographic method for simultaneous determination of clindamycin phosphate and rifampicin in skin permeation studies. Journal of Pharmaceutical And Biomedical Analysis, v. 159, p. 331-340, 2018.

PINHO, L. A. G.; SOUZA, S.; MARRETO, R. N.; BARRETO, L. C.; GRATIERI, T.;GELFUSO, G. M.; CUNHA FILHO, M. S. S. Dissolution Enhancement in Cocoa Extract, Combining Hydrophilic Polymers through Hot-Melt Extrusion. Pharmaceutics, v. 10, p. 135, 2018.

TEMER, A. C.; TEIXEIRA, M. T.; SA-BARRETO, L. L.; GRATIERI, T.; GELFUSO, G. M.; SILVA, I. C.; TAVEIRA, S. F.; MARRETO, R. N.; CUNHA-FILHO, M. Subdivision of Tablets Containing Modified Delivery Technology: the Case of Orally Disintegrating Tablets. Journal of Pharmaceutical Innovation, v. 13, p. 261-269, 2018.

LIMA, S.G.B.; PINHO, L.A.G.; PEREIRA, M.N.; GRATIERI, T.; SA-BARRETO, L.L.;GELFUSO, G.M.; CUNHA-FILHO, M. Preformulation studies of finasteride to design matrix systems for topical delivery. Journal of Pharmaceutical And Biomedical Analysis, v. 161, p. 273-279, 2018.

PIMENTA, B. C. R.; QUINTÃO, T. S. C.; CHAKER, J. A.; OLIVEIRA, P. M.; GELFUSO, G. M.; KARNIKOWSKI, M. G. O.; GRIS, E. F. Improving stability of antioxidant compounds from Plinia cauliflora (jabuticaba) fruit peel extract by encapsulation in chitosan microparticles. Journal of Food Engineering, v. 238, p. 195-201, 2018.

SOARES, K. C. C.; SOUZA, W. C.; TEXEIRA, L. S.; CUNHA-FILHO, M. S. S.; GELFUSO, G. M.; GRATIERI, T. Comparison of clobetasol propionate generics using simplified in vitro bioequivalence method for topical drug products. Current Drug Delivery, v. 14, 2018.

GRATIERI, T.; SANTOS, A. P. K.; ROCHA, P. B. R.; CUNHA-FILHO, M. S. S.; GELFUSO, G. M.; MARRETO, R. N.; TAVEIRA, S. F. SLN- and NLC-encapsulating antifungal agents: skin drug delivery and their unexplored potential for treating onychomycosis. Current Pharmaceutical Design, 2018 (publicado online).

FERREIRA-NUNES, R.; GRATIERI, T.; GELFUSO, G. M.; CUNHA-FILHO, M. Mixture design applied in compatibility studies of catechin and lipid compounds. Journal of Pharmaceutical And Biomedical Analysis, v. 149, p. 612-617, 2018.

MALAQUIAS, L.F.B.; SCHULTE, H.L.; CHAKER, J.A.; KARAN, K.; DURIG, T.; MARRETO, R.N.; GRATIERI, T.; GELFUSO, G. M.; CUNHA-FILHO, M. Hot melt extrudates formulated using design space: one simple process for both palatability and dissolution rate improvement. Journal of Pharmaceutical Sciences, v. 107, p. 286-296, 2018.

MALAQUIAS, L. F. B.; BARRETO, L. C. S.; FREIRE, D.; SILVA, I. C. R.; KARAN, K.; DURIG, T.; LIMA, E. M.; MARRETO, R. N.; GELFUSO, G. M.; GRATIERI, T.; CUNHA-FILHO, M. S. S. Taste masking and rheology improvement of drug complexed with beta-cyclodextrin and hydroxypropyl-β-cyclodextrin by hot-melt extrusion. Carbohydrate Polymers, p. 19-26, 2018.

FERREIRA-NUNES, R.; ANGELO, T.; DA SILVA, S. M. M.; MAGALHÃES, P. O.; GRATIERI, T.; CUNHA-FILHO, M.S.S.; GELFUSO, G. M.Versatile chromatographic method for catechin determination in development of topical formulations containing natural extracts. Biomedical Chromatography, v. 32, p. e4062, 2018.

REIS, T.A.; JACULI, A.E.; ALVES, R.C.; GRATIERI, T.; AZEVEDO, R.B.; JOANITTI, G.A.; GELFUSO, G. M.; CUNHA-FILHO, M. Simple and Selective HPLC-UV/Vis Bioanalytical Method to Determine Aluminum Phthalocyanine Chloride in Skin Permeation Studies. Journal of Analytical Methods in Chemistry, v. 2018, p. 1-7, 2018.

 

OLIVEIRA, PAULA M. ; MATOS, BRENO N. ; Pereira, Priscilla A.T. ; GRATIERI, TA?S ; FACCIOLI, LUCIA H. ; CUNHA-FILHO, MARC?LIO S.S. ; Gelfuso, Guilherme M. . Microparticles prepared with 50?190 kDa chitosan as promising non-toxic carriers for pulmonary delivery of isoniazid. CARBOHYDRATE POLYMERS, v. 174, p. 421-431, 2017.

PEREIRA, MAÍRA N. ; REIS, THAIENE A. ; MATOS, BRENO N. ; CUNHA-FILHO, MARCÍLIO ; Gratieri, Taís ; Gelfuso, Guilherme M. . Novel ex vivo protocol using porcine vagina to assess drug permeation from mucoadhesive and colloidal pharmaceutical systems. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 158, p. 222-228, 2017.

CUNHA-FILHO, M. S. S. ; ARAUJO, M. R. P. ; GELFUSO, G. M. ; GRATIERI, T. . FDM 3D printing of modified drug-delivery systems using hot melt extrusion: a new approach for individualized therapy. THERAPEUTIC DELIVERY, v. 8, p. 957-966, 2017.

PINHO, L. A. G. ; LIMA, S. ; MALAQUIAS, L. F. B. ; PIRES, F. Q. ; BARRETO, L. C. S. ; CARDOZO-FILHO, L. ; GRATIERI, T. ; GELFUSO, G. M. ; CUNHA-FILHO, M. S. S. . Improvements of theobromine pharmaceutical properties using solid dispersions prepared with newfound technologies. CHEMICAL ENGINEERING RESEARCH & DESIGN, p. x, 2017.

PEREIRA, M. N.; SCHULTE, H. L.; DUARTE, N. C. B.; LIMA, E. M.; BARRETO, L. C. S.; GRATIERI, T.; GELFUSO, G. M.; CUNHA-FILHO, M. S. S. Solid effervescent formulations as new approach for topical minoxidil delivery. European Journal of Pharmaceutical Sciences, v. 96, p. 411-419, 2017.

ALENCAR, R. G.; OLIVEIRA, A. C.; LIMA, E. M.; CUNHA-FILHO, M. S. S.; TAVEIRA, S. F.; MARRETO, R. N. Compacted Multiparticulate Systems for Colon-Specific Delivery of Ketoprofen. AAPS PharmSciTech, 2017 (in press).

SERPA, R. C.; CUNHA-FILHO, M. S.S.; LIMA, E. M. Compatibility studies of entacapone with carbidopa, L-dopa, and pharmaceutical excipients for a fixed dose combination product. A technical note. Acta Farmacéutica Bonaerense, v. 36, p. 1-6, 2017.

SILVEIRA, D. G. A.; ÂNGELO, T.; PINHEIRO, R. M.; GRATIERI, T. Infusão Subcutânea Contínua de Insulina: Cenário Nacional e Internacional. Cadernos Saúde Coletiva (UFRJ), 2017 (in press).

PIRES, F. Q.; ANGELO, T.; SILVA, J. K. R.; BARRETO, L. C. S.; LIMA, E. M.; GELFUSO, G. M.; GRATIERI, T.; CUNHA-FILHO, M. S. S. Use of mixture design in drug-excipient compatibility determinations: Thymol nanoparticles case study. Journal of Pharmaceutical and Biomedical Analysis, v. 137, p. 196-203, 2017.

CARMO, A. C. M.; PIRAS, S. S.; ROCHA, N. F. M.; GRATIERI, T. Main Reasons for Registration Application Refusal of Generic and Similar Pharmaceutical Drug Products by the Brazilian Health Regulatory Agency (ANVISA). BioMed Research International, v. 2017, p. 1-10, 2017.

SILVEIRA, D. G. A.; ÂNGELO, T.; PINHEIRO, R. M.; GRATIERI, T. Horizonte tecnológico do diabetes e o cenário das pesquisas no Brasil. Brasília Médica, 2017 (in press).

TEIXEIRA, M. T.; BARRETO, L. C. S.; GRATIERI, T.; GELFUSO, G. M.; SILVA, I. C. R.; CUNHA-FILHO, M. S. S. Key Technical Aspects Influencing the Accuracy of Tablet Subdivision. AAPS PharmSciTech, 2016 (in press).

 

GELFUSO, G. M.; CUNHA-FILHO, M. S. S.; GRATIERI, T. Nanostructured lipid carriers for targeting drug delivery to the epidermal layer. Therapeutic Delivery,  v. 7, p. 735-737, 2016.

  

ANGELO, T.; PIRES, F. Q.; GELFUSO, G. M.; SILVA, J. K. R.; GRATIERI, T.; CUNHA-FILHO, M. S. S. Development and validation of a selective HPLC-UV method for thymol determination in skin permeation experiments. Journal of Chromatography B, v. 1022, p. 81-86, 2016.

 

ANGELO, T.; BORGHETI-CARDOSO, L. N.; GELFUSO, G. M.; TAVEIRA, S. F.; GRATIERI, T. Chemical and physical strategies in onychomycosis topical treatment: A review. Medical Mycology, p. myw084, 2016.

 

ALVES-SILVA, I.; MARRETO, R. N.; GELFUSO, G. M.; BARRETO, L. C. S.; LIMA, E. M.; CUNHA-FILHO, M. S. S. Preparation of benznidazole pellets for immediate drug delivery using the extrusion spheronization technique. Drug Development and Industrial Pharmacy, p. 1-26, 2016 (in press).

 

ANGELO, T.; CUNHA-FILHO, M. S. S.; GELFUSO, G. M.; GRATIERI, T. Chromatographic method for clobetasol propionate determination in hair follicles and in different skin layers. Biomedical Chromatography, v. 1022, p. 81-86, 2016.

 

MATOS, B. N.; MELO, L.; PEREIRA, M. N.; REIS, T. A.; CUNHA-FILHO, M. S. S.; GRATIERI, T.; GELFUSO, G. M. Iontophoresis on minoxidil sulphate-loaded chitosan nanoparticles accelerates drug release, decreasing their targeting effect to hair follicles. Química Nova, p. 1-4, 2016.

 

ANGELO, T.; BARBALHO, G. N.; GELFUSO, G. M.; GRATIERI, T. Minoxidil topical treatment may be more efficient if applied on damp scalp in comparison with dry scalp. Dermatologic Therapy, v. 29, p. 330-333, 2016.

 

ALONSO, E. C. P.; RICCOMINI, K.; SILVA, L. A. D.; GALTER, D.; LIMA, E. M.; DURIG, T.; TAVEIRA, S. F.; MARTINS, F. T.; CUNHA-FILHO, M. S. S.; MARRETO, R. N. Development of carvedilol-cyclodextrin inclusion complexes using fluid-bed granulation: a novel solid-state complexation alternative with technological advantages. Journal of Pharmacy and Pharmacology, v. 68, p. 1299-1309, 2016.

 

SILVA, L. A. D.; TEIXEIRA, F. V.; SERPA, R. C.; ESTEVES, N. L.; DOS SANTOS, R. R.; LIMA, E. M.; CUNHA-FILHO, M. S. S.; DE SOUZA ARAÚJO, A. A.; TAVEIRA, S. F.; MARRETO, R. N. Evaluation of carvedilol compatibility with lipid excipients for the development of lipid-based drug delivery systems. Journal of Thermal Analysis and Calorimetry, v. 123, p. 2337-2344, 2016.

 

PINHO, L. A. G.; SÁ-BARRETO, LÍVIA C. L.; INFANTE, C. M.; CUNHA-FILHO, M. S. S. Simultaneous determination of benznidazole and itraconazole using spectrophotometry applied to the analysis of mixture: A tool for quality control in the development of formulations. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, p. 48-52, 2016.

 

SILVA, L. A. D.; ANDRADE, L. M.; DE SÁ, F. A. P.; MARRETO, R. N.; LIMA, E. M.; GRATIERI, T.; TAVEIRA, S. F. Clobetasol-loaded nanostructured lipid carriers for epidermal targeting. Journal of Pharmacy and Pharmacology, v. 68, p. 742-750, 2016.

 

BORGUETI-CARDOSO, L. N.; BICENTINI, F. T. M. C.; GRATIERI, T.; BENTLEY, M. V. L. B. Liquid crystalline systems containing Vitamin E TPGS for the controlled transdermal nicotine delivery. Brazilian Journal of Pharmaceutical Sciences, v. 52, p. 191-200, 2016.

 

ANDRADE, L. M.; ROCHA, K. A. D.; SA, F. A. P.; MARRETO, R. N.; GRATIERI, T.; LIMA, E. M.; TAVEIRA, S. F. Voriconazole-Loaded Nanostructured Lipid Carriers for Ocular Drug Delivery. Cornea, v. 35, p. 866-871, 2016.

BORGHETI-CARDOSO, L. N.; ANGELO, T.; GELFUSO, G. M.; LOPEZ, R. F. V.; GRATIERI, T. Topical and transdermal delivery of drug-loaded nano/microsystems with application of physical enhancement techniques. Current Drug Targets, v. 17, p. 1545-1559, 2016.

 

MATOS, B. N.; OLIVEIRA, P. M.; REIS, T. A.; GRATIERI, T. ; CUNHA-FILHO, M.; GELFUSO, G. M. Development and validation of a simple and selective analytical HPLC method for the quantification of oxaliplatin. Journal of Chemistry, v.2015, p. 1-6, 2015.

 

QUINTAO, W. S. C. ; MATOS, B. N. ; REIS, T. A. ; BARRETO, L. C. S. ; GRATIERI, T. ; GELFUSO, G. M. Influence of monoolein on progesterone transdermal delivery. Brazilian Journal of Pharmaceutical Sciences, v. 51, n.4, 2015.

 

SILVA, L. A. D.; TEIXEIRA, F. V.; SERPA, R. C.; ESTEVES, N. L.; SANTOS, R. R.; LIMA, E. M.; CUNHA-FILHO, M. S. S.; ARAUJO, A. A. S.; TAVEIRA, S. F.; MARRETO, R. N. Evaluation of carvedilol compatibility with lipid excipients for the development of lipid-based drug delivery systems. Journal of Thermal Analysis and Calorimetry, p. 1-8, 2015.

 

BITENCOURT, C. S.; SILVA, L. B.; PEREIRA, P. A. T.; GELFUSO, G. M.; FACCIOLI, L. H. Microspheres prepared with different co-polymers of poly(lactic-glycolic acid) (PLGA) or with chitosan cause distinct effects on macrophages. Colloids and Surfaces. B, Biointerfaces, v. 136, p. 678-686, 2015.

 

DE SA, F. A.; TAVEIRA, S. F.; GELFUSO, G. M.; LIMA, E. M.; GRATIERI, T. Liposomal voriconazole (VOR) formulation for improved ocular delivery. Colloids and Surfaces. B, Biointerfaces, v. 133, p. 331-338, 2015.

 

GELFUSO, G. M.; BARROS, M. A. O.; DELGADO-CHARRO, M. B.; Guy, Richard H.; LOPEZ, R. F. V. Iontophoresis of minoxidil sulphate loaded microparticles, a strategy for follicular drug targeting? Colloids and Surfaces. B, Biointerfaces, v. 134, p. 408-412, 2015.

 

PEREIRA, P. P. T.; BITENCOURT, C. S.; SANTOS, D. F.; NICOLETE, R.; GELFUSO, G. M.; FACCIOLI, L. H. Prostaglandin D2-loaded microspheres effectively activate macrophage effector functions. European Journal of Pharmaceutical Sciences, v. 78, p. 132-139, 2015.

 

SOARES, K. C. C.; SANTOS, G. M. L.; GELFUSO, G. M.; GRATIERI, T. An Update of the Brazilian Regulatory Bioequivalence Recommendations for Approval of Generic Topical Dermatological Drug Products. The AAPS Journal, v. 17, p. 1517-1518, 2015.

 

BITENCOURT, C. S.; GELFUSO, G. M.; PEREIRA, P. A. T.; ASSIS, P. A.; TEFE-SILVA, C.; RAMOS, S. G.; ARANTES, E. C.; FACCIOLI, L. H. Hyaluronidase-loaded PLGA microparticles as a new strategy for the treatment of pulmonary fibrosis. Tissue Engineering. Part A, v. 21, p. 246-56, 2015.

 

MATOS, B. N. ; REIS, T. A. ; GRATIERI, T. ; GELFUSO, G. M . Chitosan nanoparticles for targeting and sustaining minoxidil sulphate delivery to hair follicles. International Journal of Biological Macromolecules, v. 75, p. 225-9, 2015.

SOARES, K. C. C. ; VOGLER, M. ; GELFUSO, G. M. ; GRATIERI, T. Bioequivalence of dermatological topical medicines: the Brazilian scenario and the health surveillance challenges. Ciência e Saúde Coletiva, v. 20, p. 3599-3608, 2015.

 

REIS, T. A. ; BARRETO, L. C. S. ; CUNHA-FILHO, M. S. S. ; GRATIERI, T. ; GELFUSO, G. M. Microagulhas: estado da arte e aplicações médicas. Brasília Médica, v. 51, p. 159-168, 2014.

 

GRATIERI, T.; KALIA, Y. N. Targeted local simultaneous iontophoresis of chemotherapeutics for topical therapy of head and neck cancers. International Journal of Pharmaceutics, v. 460, p. 24-27, 2014.

 

SILVA, I. A.; SÁ BARRETO, L. C. L.; LIMA E. M.; CUNHA-FILHO, M. S. S. Preformulation studies of itraconazole associated with benznidazole and pharmaceutical excipients. Thermochimica Acta, v. 575, p. 29-33, 2014.

 

CUNHA-FILHO, M. S. S.; GUSTMANN P.C.; SANCHES-GARCIA F.; LIMA E. M.; SÁ-BARRETO, L. C. L. Development and physical evaluation of Maytenus ilicifolia effervescent granules using factorial design. Brazilian Journal of Pharmaceutical Sciences, v. 50, p. 243-250, 2014.

 

TALVANI, A.; BAHIA, M. T.; SÁ-BARRETO, L. C. L.; LIMA, E. M.; CUNHA-FILHO, M. Carvedilol: decomposition kinetics and compatibility with pharmaceutical excipients. Journal of Thermal Analysis and Calorimetry, v. 115, p. 2501-2506, 2014.

 

GRATIERI, T.; GELFUSO, G. Overcoming hurdles in iontophoretic drug delivery: is skin the only barrier? Therapeutic Delivery, v. 5, p. 493-496, 2014.

 

GRATIERI, T.; PUJOL-BELLO, ESTER; GELFUSO, G. M.; DE SOUZA, JOEL G.; LOPEZ, RENATA F.V.; KALIA, Y. N. Iontophoretic transport kinetics of ketorolac in vitro and in vivo: Demonstrating local enhanced topical drug delivery to muscle. European Journal of Pharmaceutics and Biopharmaceutics, v. 86, p. 219-226, 2014.

 

GELFUSO, G. M.; GRATIERI, T.; DELGADO-CHARRO, M. B.; GUY, R. H. Iontophoresis-targeted, follicular delivery of minoxidil sulphate for the treatment of alopecia. Journal of Pharmaceutical Sciences, v. 102, p. 1488-1494, 2013.

 

GRATIERI, T.; KALIA, Y. N. Mathematical models to describe iontophoretic transport in vitro and in vivo and the effect of current application on the skin barrier. Advanced Drug Delivery Reviews, v. 65, p. 315-329, 2013.

 

GRATIERI, T.; ALBERTI, I.; LAPTEVA, M.; KALIA, Y. N. Next generation intra- and transdermal therapeutic systems: Using non- and minimally-invasive technologies to increase drug delivery into and across the skin. European Journal of Pharmaceutical Sciences, v. 50, p. 609-622, 2013.

 

CUNHA-FILHO, M. S. S.; MARTINEZ-PACHECO, R.; LANDIN, M. Effect of storage conditions on the stability of β-lapachone in solid state and in solution. Journal of Pharmacy and Pharmacology, v. 65, p. 798-806, 2013.

 

GRATIERI, T.; CARDOSO, L. N. B.; GELFUSO, G. M.; CUNHA-FILHO, M. S. S. Injeção? Sem agulha, por favor. Ciência Hoje, v. 51, p. 28-31, 2013.

 

SÁ-BARRETO, LÍVIA C. L.; GUSTMANN, PRICILA C.; GARCIA, FELIPE S.; MAXIMIANO, FLÁVIA P.; NOVACK, KÁTIA M.; CUNHA-FILHO, M. S. S. Modulated dissolution rate from the inclusion complex of antichagasic benznidazole and cyclodextrin using hydrophilic polymer. Pharmaceutical Development and Technology, v. 18, p. 1035-1041, 2013.

 

BORGHETI-CARDOSO, L. N.; CUNHA-FILHO, M. S. S.; GELFUSO, G. M.; GRATIERI, T. Injeção sem agulhas: aplicações médicas e perspectivas futuras. Brasília Médica, v. 50, p. 257-264, 2013.

 

CUNHA-FILHO, M. S. S.; MARTINEZ-PACHECO, R.; LANDIN, M. Fast dissolving beta-lapachone particles and tablets: an approach using surface adsorption technique. Drug Development and Industrial Pharmacy, v. 38, p. 866-871, 2012.

 

CUNHA-FILHO, MARCILIO S. S.; ALVAREZ-LORENZO, CARMEN; MARTÍNEZ-PACHECO, RAMÓN; LANDIN, M. Temperature-sensitive gels for intratumoral delivery of B-Lapachone: effect of cyclodextrins and ethanol. The Scientific World Journal, v. 2012, p. 1-8, 2012.

 

CUNHA-FILHO, M. S. S.; SÁ BARRETO, L. C. L.; LEONARDI, D.; LAMAS, M. C.; SALOMON, C. J. Recentes avanços no tratamento da doença de Chagas. Brasília Médica, v. 49, p. 279-283, 2012.

 

GRATIERI, T.; WAGNER, B.; KALARIA, D.; ERNST, B.; KALIA, Y. N. Cutaneous iontophoretic delivery of CGP69669A, a sialyl Lewisx mimetic, in vitro. Experimental Dermatology, v. 21, p. 226-228, 2012.

 

GRATIERI, T.; WAGNER, B.; KALARIA, D.; ERNST, B.; KALIA, Y. N. Development and validation of a HPAE-PAD method for the quantification of CGP69669A, a sialyl Lewisx mimetic, in skin permeation studies. BMC. Biomedical Chromatography, v. 26, p. 507-511, 2012.

 

LAPTEVA, M.; ALBERTI, I.; CHEN, Y.; GRATIERI, T.; KALARIA, D.; KALIA, Y. N. Redefining the limits of transdermal drug delivery: New technologies for the non- and minimally-invasive delivery of peptides and proteins into the skin. APV Focus Group Drug Delivery, v. 2/2012, p. 4-11, 2012.

 

SOUZA, J. G.; GELFUSO, G. M.; SIMÃO, P. S.; BORGES, A. C.; LOPEZ, R. F. V. Iontophoretic transport of zinc phthalocyanine tetrasulfonic acid as a tool to improve drug topical delivery. Anti-Cancer Drugs, v. 22, p. 783-793, 2011.

 

DOS SANTOS, D. F.; BITENCOURT, C. S.; GELFUSO, G. M.; PEREIRA, P. A. T.; SOUZA, P. R.; SORGI, C. A.; NICOLETE, R.; FACCIOLI, L. H. Biodegradable microspheres containing leukotriene B4 and cell-free antigens from Histoplasma capsulatum activate murine bone marrow-derived macrophages. European Journal of Pharmaceutical Sciences, v. 44, p. 580-588, 2011.

 

PEREIRA, P. A. T. ; BITENCOURT, C. S. ; GELFUSO, G. M. ; SECATTO, A. ; SADIKOT, R.T. ; FACCIOLI, L. H. PLGA microspheres loading prostanoids are phagocytized by alveolar macrophage: a possible immune protection during histoplasmosis. Inflammation Research, v. 60, p. 117-118, 2011.

 

GELFUSO, G.M.; GRATIERI, T.; SOUZA, J. G.; THOMAZINE, J. A.; LOPEZ, R. F. V. The influence of positive or negative charge in the passive and iontophoretic skin penetration of porphyrins used in topical photodynamic therapy. European Journal of Pharmaceutics and Biopharmaceutics, v. 77, p. 249-256, 2011.

 

GRATIERI, T.; KALARIA, D.; KALIA, Y. N. Non-invasive iontophoretic delivery of peptides and proteins across the skin. Expert Opinion on Drug Delivery, v. 8, p. 645-663, 2011.

 

GRATIERI, T.; GELFUSO, G.M.; DE FREITAS, O.; ROCHA, E. M.; LOPEZ, R. F. V. Enhancing and sustaining the topical ocular delivery of fluconazole using chitosan solution and poloxamer/chitosan in situ forming gel. European Journal of Pharmaceutics and Biopharmaceutics, v. 1, p. 1010-16, 2011.

 

GRATIERI, T.; KALIA, Y. N. New technologies for topical delivery and their applications in aesthetic dermatology. Kosmetische Medizin / Cosmetic Medicin, v. 4, p. 165-174, 2011.

 

GELFUSO, G. M.; GRATIERI, T.; SIMÃO, P. S.; DE FREITAS, L. A. P.; LOPEZ, R. F. Chitosan microparticles for sustaining the topical delivery of minoxidil sulphate. Journal of Microencapsulation, v. 28, p. 650-658, 2011.

 

ALVES V. M. L.; SÁ BARRETO, L. C. L.; SOUZA, G. B.; CUNHA-FILHO, M. Co-processed extracts of Cassia angustifolia Vahl. (Fabaceae) and Maytenus ilicifolia Mart. ex Reiss (Celastraceae) for production of high load tablets. Revista Brasileira de Farmacognosia, v. 21, p. 510-517, 2011.

 

MAXIMIANO, F. P.; NOVACK, K. M.; BAHIA M.T.; SÁ BARRETO, L. C. L.; CUNHA-FILHO, M. Polymorphic screen and drug-excipient compatibility studies of the antichagasic benznidazole. Journal of Thermal Analysis and Calorimetry, v. 106, p. 819-824, 2011.

 

MAXIMIANO, F. P.; PAULA L.M.; FIGUEIREDO V. P.; ANDRADE I. M.; TALVANI, A.; SÁ BARRETO, L. C. L.; BAHIA M.T.; CUNHA-FILHO, M. Benznidazole microcrystal preparation by solvent change precipitation and in vivo evaluation in the treatment of Chagas disease. European Journal of Pharmaceutics and Biopharmaceutics, v. 78, p. 377-384, 2011.

 

MAXIMIANO, F. P.; COSTA, G. H. Y.; SÁ BARRETO, L. C. L.; BAHIA M.T.; CUNHA-FILHO, M. Development of effervescent tablets containing benznidazole complexed with cyclodextrin. Journal of Pharmacy and Pharmacology, v. 63, p. 786-793, 2011.

 

CUNHA-FILHO, M.; ESTEVEZ-BRAUN, A.; PÉREZ-SACAU, E.; ECHEZARRETA-LÓPEZ, M.; MARTINEZ-PACHECO, R.; LANDIN, M. Light effect on the stability of beta-lapachone in solution. Pathways and kinetics. Journal of Pharmacy and Pharmacology, v. 63, p. 1156-1160, 2011.

 

MAXIMIANO, F. P.; COSTA, G. H. Y.; SOUZA, J.; CUNHA-FILHO, M. Caracterização físico-química do fármaco antichagásico benznidazol. Química Nova, v. 33, p. 1714-1719, 2010.

 

GRATIERI, T.; GELFUSO, G.M.; THOMAZINI, J.A.; LOPEZ, R. F. Excised porcine cornea integrity evaluation in an in vitro model of iontophoretic ocular research. Ophthalmic Research, v. 43, p. 208-216, 2010.

 

GRATIERI, T.; GELFUSO, G. M.; ROCHA, E. M.; SARMENTO, V. H.; DE FREITAS, O.; LOPEZ, R. F. V. A poloxamer/chitosan in situ forming gel with prolonged retention time for ocular delivery. European Journal of Pharmaceutics and Biopharmaceutics, v. 75, p. 186-193, 2010.

 

GRATIERI, T.; GELFUSO, G. M.; LOPEZ, RENATA F. V.; SOUTO, E. B. Current efforts and the potential of nanomedicine in treating fungal keratitis. Expert Review of Ophthalmology, v. 5, p. 365-384, 2010.

 

GRATIERI, T.; SHAEFER, U.F.; JING, L.; GAO, M.; KOSTKA, K.H.; LOPEZ, R.F.V.; SCHNEIDER, M. Penetration of Quantum Dot particles through human skin. Journal of Biomedical Nanotechnology, v. 6, p. 586-595, 2010.

 

SIMONETTI, L. D.; GELFUSO, G. M.; BARBOSA, J. C.; LOPEZ, R. F. V. Assessment of the percutaneous penetration of cisplatin: the effect of monoolein and the drug skin penetration pathway. European Journal of Pharmaceutics and Biopharmaceutics, v. 73, p. 90-94, 2009.

 

SÁ BARRETO, L. C. L.; CUNHA FILHO, M. S. S. Excipientes co-processados para compressão direta de comprimidos. Acta Farmaceutica Bonaerense, v. 28, p. 304-312, 2009.

 

CUNHA FILHO, M. S. S.; SÁ BARRETO, L. C. L.; MARTINEZ-PACHECO, R.; LANDIN, M. Validação da metodologia analítica e desenvolvimento do teste de dissolução para o antineoplásico beta-lapachona. Acta Farmaceutica Bonaerense, v. 28, p. 805-811, 2009.

 

GRATIERI, T.; GELFUSO, G. M.; LOPEZ, R. F. Medição do futuro: iontoforese facilita entrada de fármaco no organismo. Ciência Hoje, v. 259, p. 20-25, 2009.

 

GELFUSO, G. M.; FIGUEIREDO, F.; GRATIERI, T.; LOPEZ, R. F. The Effects of pH and Ionic Strength on Topical Delivery of a Negatively Charged Porphyrin (TPPS4). Journal of Pharmaceutical Sciences, v. 97, p. 4249-4257, 2008.

 

GRATIERI, T.; GELFUSO, G. M.; LOPEZ, R. F. Princípios básicos e aplicação da iontoforese na penetração cutânea de fármacos. Química Nova, v. 31, p. 1490, 2008.

 

CUNHA FILHO, M. S. S.; SOARES SOBRINHO, J. L.; ROLIM NETO, P. J.; TORRES-LABANDEIRA, J. J.; DACUNHA-MARINHO, B. Benznidazole. Acta Crystallographica. Section E, v. E64, p. 634, 2008.

 

SÁ BARRETO, L. C. L.; CUNHA FILHO, M. S. S. Ciclodextrina: importante excipiente farmacêutico funcional. Acta Farmaceutica Bonaerense, v. 27, p. 629-636, 2008.

 

CUNHA-FILHO, M.; MARTINEZPACHECO, R.; LANDIN, M. Dissolution rate enhancement of the novel antitumoral beta-lapachone by solvent change precipitation of microparticles. European Journal of Pharmaceutics and Biopharmaceutics, v. 69, p. 871-877, 2008.

 

SÁ BARRETO, L. C. L.; CUNHA FILHO, M. S. S.; SOUZA, I. A.; XAVIER, H. S. Avaliação preliminar da atividade biológica e toxicidade aguda de Vitex gardneriana Schauer (Verbenaceae). Acta Farmaceutica Bonaerense, v. 27, p. 909-913, 2008.

 

HERAI, H.; GRATIERI, T.; THOMAZINE, J. A.; BENTLEY, M. V. L. B.; LOPEZ, R. F. V. Doxorubicin skin penetration from monoolein-containing propylene glycol formulations. International Journal of Pharmaceutics, v. 329, p. 88-93, 2007.

 

CUNHA FILHO, M. S. S.; DACUNHA-MARINHO, B.; TORRES-LABANDEIRA, J. J.; MARTINEZ-PACHECO, R.; LANDIN, M. Characterization of beta-lapachone and methylated beta-cyclodextrin solid-state systems. AAPS PharmSciTech, v. 8, p. 60, 2007.

 

CUNHA FILHO, M. S. S.; MARTINEZ-PACHECO, R.; LANDIN, M. Compatibility of the antitumoral beta-lapachone with different solid dosage forms excipients. Journal of Pharmaceutical and Biomedical Analysis, v. 45, p. 590-598, 2007.

 

SÁ BARRETO, L. C. L.; CARVALHO, E. F. N. B.; CUNHA FILHO, M. S. S.; FERREIRA, C. P.; XAVIER, H. S. Atividade moluscicida de extratos e de aucubina de vitex gardneriana schauer (verbenaceae) em embriões da espécie biomphalaria glabrata. Acta Farmaceutica Bonaerense, v. 26, p. 339-343, 2007.

 

CUNHA FILHO, M. S. S.; SÁ BARRETO, L. C. L. Utilização de ciclodextrinas na formação de complexos de inclusão de interesse farmacêutico. Revista de Ciências Farmacêuticas Básica e Aplicada, v. 28, p. 1-9, 2007.

 

CUNHA FILHO, M. S. S.; LANDIN, M.; MARTINEZ-PACHECO, R.; DACUNHA-MARINHO, B. Beta-lapachone. Acta Crystallographica. Section C, Crystal Structure Communications, v. C62, p. 473-475, 2006.

 

CUNHA FILHO, M. S. S.; ALVES, F. C.; ALVES, G. M. C.; MONTEIRO, D. B.; MEDEIROS, F. P. M.. Beta-lapachona: desenvolvimento e validação de metodologia analítica para nova alternativa terapêutica antineoplásica. Revista Brasileira de Farmácia, v. 86, p. 39-43, 2005.

 

OLIVEIRA FILHO, A.; SOARES SOBRINHO, J. L.; NUNES, L. C.; ROCA, M. F.; CUNHA FILHO, M. S. S. Sistema de liberação prolongada a partir de comprimidos matriciais bioadesivos vaginais contendo metronidazol. Revista de Ciências Farmacêuticas Básica e Aplicada, v. 26, p. 217-220, 2005

 

LTMAC. Prédio da Faculdade de Ciências da Saúde, Sala AC109. Universidade de Brasília. Campus Universitário Darcy Ribeiro. 70910-900. Brasília, DF, Brazil